In this discussion, CLI Global Society Publications Committee members Fadi Saab, MD, Zola N’Dandu, MD, KJ Nagarsheth, MD, and Bret Wiechmann, MD discuss the role the Committee plays in challenging the status quo and changing how patients with CLI are treated.

The definition and treatment of CLTI have been evolving, recognizing the importance of early recognition and aggressive treatment required for those patients. In this article, the authors discuss the historical definitions of CLTI and provide an overview of how the management of patients with CLTI has developed, including surgical and endovascular interventions.

This review focuses on specific noninvasive diagnostic tools that aid in corroborating findings on history and physical examination and provide guidance for the optimal critical limb-threatening management strategy.     

We review here the mechanism of action of OA, supporting clinical study evidence, and corresponding economic analyses.